Description

Piperazine, 2,5-Bis(Fluoromethyl)-, trans- (9Ci) is a specialized fluorinated piperazine derivative, a high-value building block in advanced organic synthesis. Its core value lies in the strategic incorporation of two fluoromethyl groups, which can significantly alter the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients where fluorine substitution is a key design strategy.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the fluorinated piperazine core enhances bioactivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with unique surface properties.
• Chemical Biology Probes: Useful for creating fluorinated analogs of biological molecules to study protein-ligand interactions and metabolic pathways.

Basic Information

Product Name	Piperazine, 2,5-Bis(Fluoromethyl)-, trans- (9Ci)
CAS No.	790625-04-6
Molecular Formula	C8H14F2N2
Molecular Weight	176.21 g/mol
Synonyms	trans-2,5-Bis(fluoromethyl)piperazine; 2,5-Bis(fluoromethyl)piperazine (trans-); 1,4-Diazacyclohexane, 2,5-bis(fluoromethyl)-, trans-; (2R,5R)-2,5-Bis(fluoromethyl)piperazine; (2S,5S)-2,5-Bis(fluoromethyl)piperazine; trans-2,5-Di(fluoromethyl)piperazine; 790625-04-6 (CAS)
EINECS	Contact for details

Quality Control

Our Piperazine, 2,5-Bis(Fluoromethyl)-, trans- (9Ci) is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, chiral purity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.