Description

Ho-Peg8-Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group at one terminus and a carboxylic acid group at the other, linked by an 8-unit PEG spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the controlled linkage of molecules with different functionalities. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic reagent development to create stable, soluble, and biocompatible conjugates.

Application

• Bioconjugation Reagent: Used for coupling peptides, proteins, or antibodies to surfaces, nanoparticles, or other biomolecules via its orthogonal hydroxyl and carboxyl reactive groups.
• PEGylation Linker: Serves as a key intermediate in the PEGylation of therapeutic proteins and peptides to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Drug Delivery Systems: Incorporated into the design of prodrugs, polymer-drug conjugates, and micellar or liposomal formulations to improve pharmacokinetic profiles.
• Diagnostic Assay Development: Employed in the synthesis of labeled probes and reagents for immunoassays, biosensors, and in-vivo imaging agents.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinker or functional monomer in the creation of biocompatible hydrogels and scaffolds for tissue engineering.
• Surface Functionalization: Used to modify the surface properties of materials (e.g., gold nanoparticles, quantum dots, chromatography media) to introduce reactive carboxylic acid groups for further coupling.

Basic Information

Product Name	Ho-Peg8-Ch2Cooh
CAS No.	780006-30-6
Molecular Formula	C19H38O11
Molecular Weight	442.5 g/mol
Synonyms	8-Amino-3,6-dioxaoctanoic acid, 17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-oic acid; HO-PEG8-COOH; α-Hydroxy-ω-carboxy octaethylene glycol; Hydroxy-PEG8-acetic acid; 2-[2-[2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; PEG8 diol monoacid; Heterobifunctional PEG 8, hydroxyl/acid
EINECS	Contact for details

Quality Control

Our Ho-Peg8-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity confirmation, and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications for identity, assay, and purity by HPLC, residual solvents, and appearance. Our quality commitment supports applications in GMP and research environments where material traceability and reliability are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). To prevent degradation, containers should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	442.5 ± 5
Acid Value (Titration)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.