Description

Ho-Peg10-Tbu CAS NO 778596-26-2 is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a hydroxyl group and a tert-butyl ester-protected carboxylic acid terminus. This compound is a critical intermediate for the synthesis of advanced bioconjugates and functionalized materials, enabling precise control over molecular architecture and solubility. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require high-purity, customizable linkers for drug delivery systems, diagnostic probes, and surface modification.

Application

• Bioconjugation Linker: A key building block for attaching drugs, peptides, or imaging agents to antibodies, proteins, or nanoparticles in ADC (Antibody-Drug Conjugate) and targeted therapy development.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers to biomolecules and surfaces, enhancing solubility, stability, and circulation time while reducing immunogenicity.
• Polymer Chemistry Intermediate: Serves as a functional monomer or macroinitiator for synthesizing tailored block copolymers and smart hydrogels with cleavable linkages.
• Surface Functionalization: Enables the covalent modification of nanoparticles, quantum dots, and biosensor surfaces with bioactive ligands for diagnostic and research applications.
• Prodrug Synthesis: Facilitates the creation of prodrugs where the active pharmaceutical ingredient is released upon specific enzymatic or chemical cleavage of the linker.
• Cross-linking Agent: Employed in the preparation of cross-linked networks for drug-eluting matrices and tissue engineering scaffolds.

Basic Information

Product Name	Ho-Peg10-Tbu
CAS No.	778596-26-2
Molecular Formula	C27H54O13
Molecular Weight	586.71 g/mol
Synonyms	1-Hydroxy-3,6,9,12,15,18,21,24,27,30-decaoxadotriacontan-32-oic acid tert-butyl ester; 10,13,16,19,22,25,28,31,34,37-Decaoxanonatriacontane-1,39-diol, 39-tert-butyl ester; HO-PEG10-tBu ester; α-Hydroxy-ω-tert-butoxycarbonyl PEG10; tert-Butyl PEG10 alcohol; PEG10 linker with OH and tBu ester; Heterobifunctional PEG 10, OH/tBu
EINECS	Contact for details

Quality Control

Our Ho-Peg10-Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, consider sealing under argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.