Description

(R)-1-(4-Benzyloxyphenyl)-4-Benzyl-6-Hydroxymethyl-Piperazin-2-One is a high-purity chiral piperazinone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or building block for the creation of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new chemical entities, process chemistry, and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel drug candidates, especially for central nervous system (CNS) and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and functional groups.
• Process Development & Scale-up: Serves as a reference standard or starting material for developing and optimizing scalable synthetic routes for API manufacturing.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Chemical Biology Probes: Potential use in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	(R)-1-(4-Benzyloxyphenyl)-4-Benzyl-6-Hydroxymethyl-Piperazin-2-One
CAS No.	777934-42-6
Molecular Formula	C25H26N2O3
Molecular Weight	402.49 g/mol
Synonyms	(R)-1-(4-(Benzyloxy)phenyl)-4-benzyl-6-(hydroxymethyl)piperazin-2-one; (6R)-1-[4-(Phenylmethoxy)phenyl]-4-(phenylmethyl)-6-(hydroxymethyl)-2-piperazinone; (R)-6-(Hydroxymethyl)-1-(4-benzyloxyphenyl)-4-benzylpiperazin-2-one; UNII-9K4F8V3W4S; 9K4F8V3W4S; (R)-enantiomer of 1-(4-Benzyloxyphenyl)-4-benzyl-6-hydroxymethyl-piperazin-2-one
EINECS	Contact for details

Quality Control

Our (R)-1-(4-Benzyloxyphenyl)-4-Benzyl-6-Hydroxymethyl-Piperazin-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.