Description

p-[[[(1R,2S)-2-Aminocyclohexyl]Amino]Carbonyl]-Phosphonic Acid (CAS 777075-44-2) is a high-purity, chiral organophosphorus compound featuring a unique cyclohexylamine backbone integrated with a phosphonic acid moiety. This molecular architecture makes it a valuable intermediate for the synthesis of sophisticated active pharmaceutical ingredients (APIs) and chiral ligands for catalysis. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical sectors who require precise, stereochemically defined building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for targeted drug molecules.
• Catalyst Ligand Precursor: Serves as a building block for synthesizing specialized chiral ligands used in asymmetric synthesis and homogeneous catalysis.
• Chemical Biology Probe: Used in the development of enzyme inhibitors or molecular probes due to its phosphonic acid group, which can mimic phosphate esters.
• Advanced Material Research: Potential monomer or additive in the development of functional polymers and materials with specific chelating or surface-modifying properties.
• Agrochemical Synthesis: Intermediate for creating novel, high-efficacy crop protection agents with potentially improved environmental profiles.

Basic Information

Product Name	p-[[[(1R,2S)-2-Aminocyclohexyl]Amino]Carbonyl]-Phosphonic Acid
CAS No.	777075-44-2
Molecular Formula	C13H19N2O4P
Molecular Weight	298.27 g/mol
Synonyms	(1R,2S)-2-[[(4-Phosphonophenyl)amino]carbonyl]cyclohexanamine; 4-[[[(1R,2S)-2-Aminocyclohexyl]amino]carbonyl]benzenephosphonic Acid; (1R,2S)-N1-(4-Phosphonobenzoyl)cyclohexane-1,2-diamine; p-[(1R,2S)-2-Aminocyclohexylcarbamoyl]phosphonic Acid; (1R,2S)-2-Amino-N-(4-phosphonophenyl)cyclohexanecarboxamide; (1R,2S)-rel-2-[[(4-Phosphonophenyl)amino]carbonyl]cyclohexanamine; ACPPA; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of p-[[[(1R,2S)-2-Aminocyclohexyl]Amino]Carbonyl]-Phosphonic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project specifications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request and are issued for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.