Description

tert-Butyl 4-(Thiophen-2-Ylsulfonyl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core functionalized with a thiophene sulfonyl group and a Boc-protecting group. This compound is specifically engineered to serve as a critical building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially for CNS-targeted therapies.
• Medicinal Chemistry R&D: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacologically active molecules.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale production for new chemical entities (NCEs) under GMP conditions.
• Protease Inhibitor Synthesis: The sulfonamide and piperazine motifs make it a valuable scaffold for developing enzyme inhibitors.
• Ligand & Catalyst Development: Utilized in academic and industrial research to create novel ligands for catalysis or biochemical probes.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 4-(Thiophen-2-Ylsulfonyl)Piperazine-1-Carboxylate
CAS No.	774575-85-8
Molecular Formula	C13H20N2O4S2
Molecular Weight	332.44 g/mol
Synonyms	1-Boc-4-(2-thienylsulfonyl)piperazine; tert-Butyl 4-(2-thiophenesulfonyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(thiophen-2-ylsulfonyl)piperazine; 4-(Thiophene-2-sulfonyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-Piperazine-Thiophene Sulfonamide; 774575-85-8; N-Boc-4-(2-thienylsulfonyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Thiophen-2-Ylsulfonyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.