Description

3-{[(Benzyloxy)Carbonyl]Amino}-3-Cyclopropylpropanoic Acid is a high-purity, non-natural amino acid derivative featuring a cyclopropyl group and a Cbz-protected amine, serving as a critical chiral building block in advanced organic synthesis. Its unique structure provides a constrained, three-membered ring system that is essential for modulating the conformation, metabolic stability, and biological activity of target molecules. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors, peptide mimetics, and other bioactive small molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce the rigid cyclopropyl scaffold into peptide backbones to enhance stability against enzymatic degradation and improve binding affinity.
• Protease Inhibitor Design: Serves as a core building block for the synthesis of inhibitors targeting various proteases, where the cyclopropane moiety mimics transition states or binds in specific enzyme pockets.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects at milligram to kilogram scale.
• Academic Research: Used in university and institutional labs for methodological development in asymmetric synthesis and studies of cyclopropane chemistry.

Basic Information

Product Name	3-{[(Benzyloxy)Carbonyl]Amino}-3-Cyclopropylpropanoic Acid
CAS No.	773867-84-8
Molecular Formula	C14H17NO4
Molecular Weight	263.29 g/mol
Synonyms	3-[(Benzyloxycarbonyl)amino]-3-cyclopropylpropanoic acid; 3-(N-Cbz-amino)-3-cyclopropylpropionic acid; (3-Cyclopropyl-3-{[(phenylmethoxy)carbonyl]amino}propanoic acid); Cbz-3-amino-3-cyclopropylpropanoic acid; N-Carbobenzoxy-3-amino-3-cyclopropylpropionic acid; 3-Cyclopropyl-3-[(phenylmethoxycarbonyl)amino]propanoic acid; Z-3-Amino-3-cyclopropylpropanoic acid
EINECS	Contact for details

Quality Control

Our 3-{[(Benzyloxy)Carbonyl]Amino}-3-Cyclopropylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS, IR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.