Description

2-Bromo-5-(Phenylthio)Pyrazine is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromine substituent and a phenylthio group on the pyrazine ring, enabling versatile cross-coupling and functionalization reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing pyrazine or diaryl sulfide motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its bioisosteric potential.
• Material Science Research: Serves as a building block for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Utilized in medicinal chemistry for constructing molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Bromo-5-(Phenylthio)Pyrazine
CAS No.	767342-33-6
Molecular Formula	C10H7BrN2S
Molecular Weight	267.15 g/mol
Synonyms	2-Bromo-5-(phenylsulfanyl)pyrazine; 5-Bromo-2-(phenylthio)pyrazine; Pyrazine, 2-bromo-5-(phenylthio)-; 2-Bromo-5-phenylsulfanylpyrazine; 767342-33-6; 2-Bromo-5-(phenylmercapto)pyrazine; 5-(Phenylthio)-2-bromopyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Phenylthio)Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.