Description

2-Carboxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester CAS NO 766539-28-0 is a high-purity, protected morpholine derivative serving as a critical building block in advanced organic synthesis. Its value lies in its bifunctional structure, which provides orthogonal reactivity for the controlled construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within the fields of peptidomimetics and small molecule drug discovery.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs and protease inhibitors by incorporating the morpholine ring system.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis or as a chelating agent in metal complexes.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	2-Carboxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester
CAS No.	766539-28-0
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	tert-Butyl 2-(carboxymethyl)morpholine-4-carboxylate; 4-(tert-Butoxycarbonyl)-2-(carboxymethyl)morpholine; 2-(Carboxymethyl)-4-[(2-methyl-2-propanyl)oxycarbonyl]morpholine; Morpholine-4-carboxylic acid, 2-(carboxymethyl)-, 1,1-dimethylethyl ester; Boc-Morpholine-2-acetic acid; (4-Boc-morpholin-2-yl)acetic acid
EINECS	Contact for details

Quality Control

Our 2-Carboxymethyl-Morpholine-4-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with client specifications and industry best practices for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.