Description

Lobeglitazone Sulfate is a high-purity active pharmaceutical ingredient (API) belonging to the thiazolidinedione class of compounds. It serves as a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), making it a critical component in the development of advanced therapeutics for metabolic disorders. This compound is essential for pharmaceutical manufacturers and research institutions focused on diabetes management and metabolic syndrome research. Its consistent quality and reliable supply are paramount for ensuring the efficacy and safety of final drug formulations.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of anti-diabetic medications.
• Metabolic Disorder Research: Key reference standard and investigational compound in preclinical and clinical studies for Type 2 Diabetes.
• Drug Development: Used in the synthesis and optimization of novel PPARγ-targeting therapeutic agents.
• Analytical Standard: Serves as a high-purity standard for quality control (QC) and analytical method development (HPLC, LC-MS) in pharmaceutical laboratories.
• Biochemical Studies: Utilized in mechanistic studies to understand PPARγ signaling pathways and insulin sensitization.

Basic Information

Product Name	Lobeglitazone Sulfate
CAS No.	763108-62-9
Molecular Formula	C19H20N2O5S • H2SO4
Molecular Weight	484.50 g/mol
Synonyms	Lobeglitazone Sulphate; (5Z)-5-[[4-[2-(6-Methyl-2-pyridinyl)ethoxy]phenyl]methylene]-2,4-thiazolidinedione Sulfate; CKD-501 (sulfate salt); CS-011 (sulfate salt); Lobeglitazone Hydrogen Sulfate; 2,4-Thiazolidinedione, 5-[[4-[2-(6-methyl-2-pyridinyl)ethoxy]phenyl]methylene]-, (5Z)-, sulfate (1:1)
EINECS	Contact for details

Quality Control

Our Lobeglitazone Sulfate is manufactured under strict quality management systems, ensuring it meets the stringent requirements for pharmaceutical intermediates and APIs. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.