Description

3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its fused triazolo-pyrazine heterocyclic structure and trifluoromethyl group. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) and oncology therapeutics. The hydrochloride salt form enhances stability and handling for precise formulation work.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of novel drug candidates, particularly for CNS disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged heterocyclic scaffold.
• API Development: Serves as a precursor in the multi-step synthesis of complex target molecules for preclinical and clinical development.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study biological pathways and validate novel therapeutic targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Employed in university and institutional labs for cutting-edge organic synthesis and pharmacology projects.

Basic Information

Product Name	3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride
CAS No.	762240-92-6
Molecular Formula	C7H10ClF3N4
Molecular Weight	242.63 g/mol
Synonyms	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine HCl; 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine hydrochloride; 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoromethyl)-, hydrochloride; 762240-92-6; 3-Trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, identity confirmation, and batch-to-batch consistency suitable for research and development applications. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation upon exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.