Description

1-Benzyl 2-Methyl (2S,4R)-4-Aminopyrrolidine-1,2-Dicarboxylate is a high-purity, stereochemically defined chiral building block of significant importance in advanced organic synthesis. This compound is a critical intermediate for the development of novel pharmaceuticals, particularly in the creation of complex molecules with specific biological activities. It is primarily sought after by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry for targets such as protease inhibitors and other bioactive agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease-targeted therapies.
• Peptidomimetic Chemistry: Serves as a constrained proline analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns within drug discovery pipelines.
• Chemical Biology Probes: Used to develop tool compounds and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-Benzyl 2-Methyl (2S,4R)-4-Aminopyrrolidine-1,2-Dicarboxylate
CAS No.	762233-34-1
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	(2S,4R)-1-[(Benzyloxy)carbonyl]-4-amino-2-pyrrolidinecarboxylic acid methyl ester; Methyl (2S,4R)-4-amino-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylate; (2S,4R)-4-Amino-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester; 1-Cbz-4-amino-(2S,4R)-proline methyl ester; Cbz-(2S,4R)-4-Amino-Proline-OMe; 762233-34-1; (2S,4R)-Cbz-4-Amino-Pro-OMe
EINECS	Contact for details

Quality Control

Our production of 1-Benzyl 2-Methyl (2S,4R)-4-Aminopyrrolidine-1,2-Dicarboxylate adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical methods including HPLC, NMR, and optical rotation. We support compliance with relevant guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.