Description

Teneligliptin CAS NO 760937-92-6 is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a key class of active pharmaceutical ingredients (APIs) used in the management of type 2 diabetes. Its primary value lies in its ability to enhance glycemic control by increasing the levels of incretin hormones, which stimulate insulin secretion in a glucose-dependent manner. This high-purity compound is essential for pharmaceutical manufacturers and research institutions developing and producing advanced anti-diabetic medications.

Application

• Active Pharmaceutical Ingredient (API) in the formulation of oral anti-diabetic drugs.
• Pharmaceutical Research & Development for studying DPP-4 inhibition mechanisms and novel drug combinations.
• Reference Standard in analytical laboratories for quality control and method validation.
• Generic Drug Manufacturing for producing cost-effective alternatives to branded teneligliptin medications.
• Preclinical and Clinical Studies to evaluate pharmacokinetics, pharmacodynamics, and safety profiles.
• Formulation Development for creating fixed-dose combination therapies with other anti-diabetic agents.

Basic Information

Product Name	Teneligliptin
CAS No.	760937-92-6
Molecular Formula	C22H30N6O2S
Molecular Weight	442.58 g/mol
Synonyms	Teneligliptin Hydrate; Teneligliptin Hydrobromide Hydrate; T-6666; (2S,4S)-4-Fluoro-1-({[4-methyl-1-(propan-2-yl)-1H-pyrazol-3-yl]carbonyl}pyrrolidin-2-yl)-N-[(1r,4r)-4-(4-methyl-1,3-thiazol-2-yl)cyclohexyl]piperidine-2-carboxamide; 3-{(2S,4S)-4-[(4-Methyl-1-propan-2-ylpyrazol-3-yl)carbonyl]fluoro-2-pyrrolidinyl}-5-[4-(4-methyl-1,3-thiazol-2-yl)cyclohexyl]-1,2,4-triazine
EINECS	Contact for details

Quality Control

Our Teneligliptin is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical use. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification. We provide full traceability and Certificates of Analysis (COA) are available upon request, confirming compliance with in-house specifications aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.