Description

5-Chloro-n-{2-[4-(Methylsulfonyl)-1-Piperazinyl]Phenyl}-1-Naphthamide is a high-purity, synthetic organic compound belonging to the class of naphthamide derivatives with a piperazinyl substituent. This advanced pharmaceutical intermediate is valued for its role in the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. It is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential kinase inhibitors and other targeted small-molecule drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Tool Compound: Serves as a reference standard or probe in pharmacological and biological screening assays.
• Process Chemistry Development: Employed in scaling up synthetic routes and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services.

Basic Information

Product Name	5-Chloro-n-{2-[4-(Methylsulfonyl)-1-Piperazinyl]Phenyl}-1-Naphthamide
CAS No.	757944-21-1
Molecular Formula	C22H22ClN3O3S
Molecular Weight	443.95 g/mol
Synonyms	5-Chloro-N-[2-[4-(methylsulfonyl)piperazin-1-yl]phenyl]-1-naphthamide; 5-Chloro-N-(2-(4-(methylsulfonyl)piperazin-1-yl)phenyl)naphthalene-1-carboxamide; 1-Naphthalenecarboxamide, 5-chloro-N-[2-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-; UNII-1XJ8K2K8QN; 1XJ8K2K8QN; 5-Chloro-N-(2-(4-methanesulfonylpiperazin-1-yl)phenyl)naphthalene-1-carboxamide
EINECS	Contact for details

Quality Control

Our 5-Chloro-n-{2-[4-(Methylsulfonyl)-1-Piperazinyl]Phenyl}-1-Naphthamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.