Description

trans-tert-Butyl 3-Amino-2-Phenylpiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a chiral piperidine scaffold. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical producers focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, particularly those targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic compounds.
• API Development: Serves as a crucial building block in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined stereochemistry at multiple centers.
• Fine Chemical Production: Employed in the manufacture of specialty and custom fine chemicals for advanced applications.
• Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis and process development projects.

Basic Information

Product Name	trans-tert-Butyl 3-Amino-2-Phenylpiperidine-1-Carboxylate
CAS No.	757195-60-1
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	1-Boc-3-amino-2-phenylpiperidine (trans); tert-Butyl 3-amino-2-phenylpiperidine-1-carboxylate (trans); (2R,3S)-tert-Butyl 3-amino-2-phenylpiperidine-1-carboxylate; (2S,3R)-tert-Butyl 3-amino-2-phenylpiperidine-1-carboxylate; 1-N-Boc-3-amino-2-phenylpiperidine; trans-3-Amino-2-phenyl-1-piperidinecarboxylic acid tert-butyl ester; 757195-60-1; 3-Amino-2-phenylpiperidine-1-carboxylic acid tert-butyl ester (trans)
EINECS	Contact for details

Quality Control

Our trans-tert-Butyl 3-Amino-2-Phenylpiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.