Description

N3-Peg23-Ch2Ch2Nh2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring an azide (N3) group and a primary amine (NH2) group, separated by a 23-unit PEG spacer. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise, high-yield linkage of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceuticals, diagnostics, and advanced materials development who require reliable, high-purity linkers for creating novel conjugates, drug delivery systems, and functionalized nanomaterials.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of cytotoxic drugs, fluorophores, or other payloads to antibodies, proteins, or peptides via the amine-reactive end, followed by copper-free click chemistry with alkyne-modified molecules.
• PEGylation and Linker Chemistry: Serving as a heterobifunctional PEG linker to introduce stealth properties, improve solubility, and reduce immunogenicity of therapeutic proteins and nanoparticles.
• Surface Functionalization and Material Science: Creating functional coatings on nanoparticles, quantum dots, or biosensor surfaces for targeted binding and specific biomolecular capture.
• Polymer Synthesis and Modification: Acting as a macromonomer or chain extender in the synthesis of functional block copolymers and hydrogels with clickable handles.
• Diagnostic Assay Development: Conjugating detection probes (e.g., enzymes, dyes) to antibodies or oligonucleotides for use in ELISA, lateral flow assays, and other diagnostic platforms.
• Crosslinking and Network Formation: Utilizing both functional groups to crosslink polymers or biomacromolecules, forming stable 3D networks for tissue engineering scaffolds or controlled release matrices.

Basic Information

Product Name	N3-Peg23-Ch2Ch2Nh2
CAS No.	749244-38-0
Molecular Formula	CnH2n+4N4O23 (n varies with PEG chain)
Molecular Weight	~1100 g/mol (Average)
Synonyms	Azide-PEG23-Amine; N3-PEG23-NH2; α-Azido-ω-amino-triethylene glycol undecaethylene glycol; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamine; Heterobifunctional PEG Azide Amine (23 units); PEG23 spacer, azide and amine terminated
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical applications. Each batch is characterized to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) are available upon request, providing detailed results from analytical methods including NMR, HPLC, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Molecular Weight (MS)	Conforms (Average)
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Amine)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.