Description

4-Fmoc-Piperazine-2-(R)-Carboxylic Acid is a protected, non-proteinogenic amino acid derivative of significant importance in modern synthetic chemistry. This compound serves as a crucial chiral building block for the construction of complex molecular architectures, particularly in peptide and peptidomimetic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key reagent for the controlled, sequential assembly of peptides containing the piperazine-2-carboxylic acid scaffold.
• Peptidomimetic Drug Discovery: Used to incorporate constrained, chiral piperazine motifs into drug candidates to improve metabolic stability, bioavailability, and target selectivity.
• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Chemical Biology & Proteomics: Employed in the synthesis of specialized probes, inhibitors, and labeled peptides for studying enzyme mechanisms and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: Used to create focused libraries of compounds featuring the piperazine carboxylic acid core for biological evaluation.
• Asymmetric Synthesis: The chiral (R)-configuration makes it a valuable starting material for the asymmetric synthesis of more complex, enantiomerically pure molecules.

Basic Information

Product Name	4-Fmoc-Piperazine-2-(R)-Carboxylic Acid
CAS No.	747393-31-3
Molecular Formula	C₂₁H₂₂N₂O₄
Molecular Weight	366.41 g/mol
Synonyms	(R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid; Fmoc-D-Pip-OH; Fmoc-(R)-Piperazine-2-carboxylic Acid; 1-Fmoc-2(R)-Carboxypiperazine; (R)-1-Fmoc-piperazine-2-carboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-(2R)-piperazinecarboxylic acid; Fmoc-D-Piperazine-2-COOH; 4-[(9-Fluorenylmethyloxycarbonyl)]-(2R)-piperazinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Fmoc-Piperazine-2-(R)-Carboxylic Acid is manufactured under strict quality control protocols to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.