Description

tert-Butyl 4-(4-Aminophenylsulfonamido)piperidine-1-carboxylate is a high-purity, protected piperidine derivative featuring both a sulfonamide and a Boc-protected amine functional group. This compound is a critical pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily utilized by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological disorders, oncology, and infectious diseases.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors due to its sulfonamido-piperidine scaffold.
• Kinase Inhibitor Development: Serves as a precursor in the creation of small molecule kinase inhibitors for targeted cancer therapies.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Item	Details
Product Name	tert-Butyl 4-(4-Aminophenylsulfonamido)piperidine-1-carboxylate
CAS No.	746630-27-3
Molecular Formula	C16H25N3O4S
Molecular Weight	355.45 g/mol
Synonyms	1-Boc-4-[(4-aminophenyl)sulfonylamino]piperidine; tert-Butyl 4-[[(4-aminophenyl)sulfonyl]amino]-1-piperidinecarboxylate; 4-[(4-Aminobenzene)sulfonamido]-1-Boc-piperidine; 1-(tert-Butoxycarbonyl)-4-[(4-aminophenyl)sulfonylamino]piperidine; 4-(4-Aminophenylsulfonamido)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(4-Aminosulfanilyl)piperidine; CAS 746630-27-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Aminophenylsulfonamido)piperidine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.