Description

3-(4-Fluorobenzyl)-Piperidine Hcl is a high-purity organic building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce a fluorobenzyl-piperidine moiety into target structures.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to explore new therapeutic candidates.
• Agrochemical Synthesis: Intermediate in the development of advanced crop protection agents and pesticides.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds and probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.
• Academic Research: Used in university and institutional laboratories for fundamental organic synthesis and drug discovery projects.

Basic Information

Product Name	3-(4-Fluorobenzyl)-Piperidine Hcl
CAS No.	745817-38-3
Molecular Formula	C12H16FN•HCl
Molecular Weight	229.72 g/mol
Synonyms	3-[(4-Fluorophenyl)methyl]piperidine hydrochloride; 1-(4-Fluorobenzyl)piperidin-3-amine hydrochloride; 3-(4-Fluorobenzyl)piperidine hydrochloride; Piperidine, 3-[(4-fluorophenyl)methyl]-, hydrochloride (1:1); 745817-38-3; 3-(p-Fluorobenzyl)piperidine HCl
EINECS	Contact for details

Quality Control

Our 3-(4-Fluorobenzyl)-Piperidine Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development and commercial projects with material suitable for research use and can supply under more stringent quality agreements as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.