Description

4-(2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the orthogonal protection of the piperazine nitrogen, enabling selective functionalization for the construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, especially those targeting the central nervous system (CNS) and as kinase inhibitors.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific piperazine-based architectures.
• Peptide Mimetics & Conjugates: Facilitates the introduction of functionalized piperazine units into peptide backbones to modulate pharmacokinetic properties.
• Ligand & Catalyst Development: Employed in creating novel chelating ligands and organocatalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions for clinical trials.
• Academic & R&D Laboratories: Serves as a versatile starting material for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	4-(2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	745738-05-0
Molecular Formula	C13H26N2O3
Molecular Weight	258.36 g/mol
Synonyms	1-Boc-4-(2-hydroxypropyl)piperazine; tert-Butyl 4-(2-hydroxypropyl)piperazine-1-carboxylate; 4-(2-Hydroxypropyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-4-(2-hydroxypropyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-hydroxypropyl)piperazine; Piperazine, 4-(2-hydroxypropyl)-, 1-(1,1-dimethylethyl) ester; Boc-4-(2-hydroxypropyl)piperazine
EINECS	Contact for details

Quality Control

Our production of 4-(2-Hydroxy-Propyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment supports applications requiring material for research, development, and scale-up under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.