Description

4-[4-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Butyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture combining phthalimide and tert-butyl piperazine carboxylate functionalities. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules. It serves as a key building block for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on developing new therapeutic agents, especially in areas requiring sophisticated nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores with enhanced efficacy and selectivity.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a component in the linker or ligand design for bifunctional molecules that target proteins for degradation.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function, protein-protein interactions, and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and commercial APIs.
• Academic Research: Employed in university and institutional labs for pioneering research in organic synthesis methodologies and new therapeutic discovery.

Basic Information

Product Name	4-[4-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Butyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	745048-06-0
Molecular Formula	C21H29N3O4
Molecular Weight	387.48 g/mol
Synonyms	2-[4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)butyl]isoindoline-1,3-dione; 1-Boc-4-[4-(1,3-dioxoisoindolin-2-yl)butyl]piperazine; tert-Butyl 4-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]piperazine-1-carboxylate; N-Boc-4-(4-phthalimidobutyl)piperazine; 745048-06-0; Piperazine-1-carboxylic acid, 4-[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)butyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-[4-(1,3-Dioxo-1,3-Dihydro-Isoindol-2-Yl)-Butyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we can support development projects requiring ICH stability guidelines and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.