Description

1-Boc-4-(1H-Indazol-4-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butoxycarbonyl (Boc) group and substituted with an indazole moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates targeting various therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates, particularly in oncology and CNS research.
• Kinase Inhibitor Development: Used to construct core scaffolds for potential kinase inhibitors, leveraging the indazole pharmacophore.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or probes to study biological pathways and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Library Synthesis: Utilized in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Custom Synthesis & Contract Manufacturing: A starting material for the custom synthesis of more complex, target-specific molecules for clients.

Basic Information

Product Name	1-Boc-4-(1H-Indazol-4-Yl)Piperazine
CAS No.	744219-31-6
Molecular Formula	C16H22N4O2
Molecular Weight	302.37 g/mol
Synonyms	1-Boc-4-(1H-indazol-4-yl)piperazine; tert-Butyl 4-(1H-indazol-4-yl)piperazine-1-carboxylate; 4-(1H-Indazol-4-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(1H-indazol-4-yl)piperazine; Boc-4-(1H-Indazol-4-yl)piperazine; N-Boc-4-(1H-indazol-4-yl)piperazine; 744219-31-6; 1-Piperazinecarboxylic acid, 4-(1H-indazol-4-yl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 1-Boc-4-(1H-Indazol-4-Yl)Piperazine is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.