Description

Ethyl 1-Boc-Piperazine-2-Carboxylate Hcl is a high-purity, protected piperazine derivative essential for advanced pharmaceutical synthesis and chemical research. This compound serves as a critical chiral building block for constructing complex molecules, offering precise control over stereochemistry in drug development pipelines. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the production of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potent drug candidates, particularly in central nervous system (CNS) and oncology research.
• Peptidomimetic Chemistry: Used to introduce constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed as a building block in the development of novel herbicides and fungicides with specific chiral requirements.
• Catalyst and Ligand Preparation: Serves as a precursor for synthesizing chiral catalysts and ligands used in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	Ethyl 1-Boc-Piperazine-2-Carboxylate Hcl
CAS No.	741288-80-2
Molecular Formula	C₁₂H₂₂N₂O₄·HCl
Molecular Weight	294.78 g/mol
Synonyms	1-Boc-2-(Ethoxycarbonyl)piperazine Hydrochloride; Ethyl 1-(tert-Butoxycarbonyl)piperazine-2-carboxylate Hydrochloride; 1-(tert-Butoxycarbonyl)piperazine-2-carboxylic Acid Ethyl Ester Hydrochloride; Ethyl 1-Boc-piperazine-2-carboxylate HCl; 1-Boc-piperazine-2-carboxylic Acid Ethyl Ester Hydrochloride; tert-Butyl 2-(ethoxycarbonyl)piperazine-1-carboxylate Hydrochloride; BOC-Pip(2-COOEt)-HCl
EINECS	Contact for details

Quality Control

Our Ethyl 1-Boc-Piperazine-2-Carboxylate Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and cGMP (current Good Manufacturing Practice) starting material applications. Certificates of Analysis (COA) with full traceability are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.