Description

(S)-1-Boc-2-Methylsulfonylethyl-Piperazine CAS NO 740806-59-1 is a high-purity, chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, enabling the development of targeted therapeutics with high efficacy. This compound is essential for research chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for creating active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Chemistry: Used to introduce constrained, sulfone-containing piperazine motifs into peptide backbones to enhance metabolic stability and receptor binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands used in asymmetric catalysis and metal-organic frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Protease Inhibitor Scaffolds: The sulfonylethyl-piperazine structure is relevant for developing inhibitors of various enzymatic targets.

Basic Information

Product Name	(S)-1-Boc-2-Methylsulfonylethyl-Piperazine
CAS No.	740806-59-1
Molecular Formula	C12H24N2O4S
Molecular Weight	292.40 g/mol
Synonyms	1-Boc-2-(2-methylsulfonylethyl)piperazine, (S)-enantiomer; tert-Butyl (S)-4-(2-(methylsulfonyl)ethyl)piperazine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-4-(2-(methylsulfonyl)ethyl)piperazine; (S)-N-Boc-2-Methylsulfonylethylpiperazine; (S)-1-Boc-2-(Methylsulfonylethyl)piperazine; (S)-Boc-Piperazine Methyl Sulfone Derivative; (S)-1-Boc-4-(2-(Methylsulfonyl)ethyl)piperazine; (S)-Boc-Protected Methylsulfonylethyl Piperazine
EINECS	Contact for details

Quality Control

Our (S)-1-Boc-2-Methylsulfonylethyl-Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.