Description

Anagliptin is a highly selective and potent dipeptidyl peptidase-4 (DPP-4) inhibitor, a key class of active pharmaceutical ingredients (APIs) for managing type 2 diabetes. Its primary value lies in its ability to enhance the body's natural insulin secretion in a glucose-dependent manner, offering a targeted therapeutic approach. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing advanced anti-diabetic medications and conducting related metabolic disease studies. Anagliptin CAS NO 739366-20-2 represents a critical component in the global fight against diabetes, requiring the highest standards of purity and consistency.

Application

• Active Pharmaceutical Ingredient (API) in the commercial production of oral anti-diabetic medications.
• Formulation Development for fixed-dose combination drugs with other anti-diabetic agents like metformin.
• Pharmaceutical Research & Development for studying DPP-4 inhibition mechanisms and efficacy.
• Reference Standard in analytical laboratories for quality control and method validation of drug products.
• Clinical Trial Material for investigational new drug (IND) applications and studies.
• Biochemical Research as a tool compound for investigating incretin hormone physiology and metabolic pathways.

Basic Information

Product Name	Anagliptin
CAS No.	739366-20-2
Molecular Formula	C19H25N7O2
Molecular Weight	383.45 g/mol
Synonyms	SYR-322; Anagliptin hydrate; 2-({6-[(2R)-2-Aminopropyl]-1,2,4-triazolo[4,3-a]pyrazin-8-yl}methyl)-4-methyl-3,4-dihydro-1(2H)-isoquinolinone; (2R)-2-({8-[(3,4-Dihydro-4-methyl-3-oxo-1(2H)-isoquinolyl)methyl]-1,2,4-triazolo[4,3-a]pyrazin-6-yl}methyl)-1-pyrrolidinecarbonitrile
EINECS	Contact for details

Quality Control

Our Anagliptin is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) that detail all critical quality attributes, ensuring compliance with ICH guidelines and customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.