Description

2-(Piperidin-4-Yl)Pyrazine Dihydrochloride is a high-purity, versatile heterocyclic building block and intermediate of significant importance in modern organic synthesis. Its core value lies in its unique fused piperidine-pyrazine structure, which is highly sought after for constructing complex molecules with potential biological activity. This compound is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its privileged scaffold.
• Agrochemical Development: Serves as a precursor in the creation of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probes: Utilized in the development of molecular probes and tool compounds for studying biological pathways and target validation.
• Ligand Synthesis: Acts as a core structure for synthesizing ligands in catalysis and for metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up under cGMP or ISO standards.

Basic Information

Product Name	2-(Piperidin-4-Yl)Pyrazine Dihydrochloride
CAS No.	736134-74-0
Molecular Formula	C9H14Cl2N3
Molecular Weight	235.13 g/mol
Synonyms	2-(4-Piperidinyl)pyrazine dihydrochloride; 4-Pyrazin-2-ylpiperidine dihydrochloride; Pyrazine, 2-(4-piperidinyl)-, dihydrochloride; 2-Pyrazinyl-4-piperidine dihydrochloride; Piperidine, 4-(2-pyrazinyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Piperidin-4-Yl)Pyrazine Dihydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to relevant ISO and cGMP guidelines for advanced intermediates, ensuring suitability for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.