Description

2,5-Piperazinedione,3,3-Bis(Hydroxymethyl)-6-Methyl-,(6S)-(9Ci) is a high-purity, stereochemically defined piperazinedione derivative, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex molecules with precise stereochemical control, which is paramount for developing active pharmaceutical ingredients (APIs) with high efficacy and safety profiles. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries, particularly those focused on peptidomimetics, constrained peptides, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Peptidomimetic Scaffold: Used to construct conformationally restricted peptide analogs, enhancing metabolic stability and receptor selectivity in drug discovery.
• Asymmetric Synthesis: Employed as a building block in asymmetric catalytic reactions and for introducing chiral centers in complex organic molecules.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to explore new chemical entities and optimize drug candidate properties.
• Bioconjugation & Probe Development: Serves as a functionalized core for creating biochemical probes, diagnostic agents, or targeted drug delivery systems.
• Fine Chemical Synthesis: Applied in the custom synthesis of specialty chemicals for agrochemical and material science applications requiring specific chirality.

Basic Information

Product Name	2,5-Piperazinedione,3,3-Bis(Hydroxymethyl)-6-Methyl-,(6S)-(9Ci)
CAS No.	732275-30-8
Molecular Formula	C9H14N2O4
Molecular Weight	214.22 g/mol
Synonyms	(6S)-3,3-Bis(hydroxymethyl)-6-methylpiperazine-2,5-dione; (S)-3,3-Bis(hydroxymethyl)-6-methyl-2,5-diketopiperazine; (S)-3,3-Bis(hydroxymethyl)-6-methylpiperazine-2,5-dione; (S)-6-Methyl-3,3-bis(hydroxymethyl)piperazine-2,5-dione; (S)-3,3-Bis(hydroxymethyl)-6-methyl-2,5-piperazinedione; (S)-3,3-Bis(hydroxymethyl)-6-methyl-DKP; Chiral Diketopiperazine Derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,3,3-Bis(Hydroxymethyl)-6-Methyl-,(6S)-(9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.