Description

1-(4-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carboxylic acid core and trifluoromethyl benzyl moiety. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in developing new therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperidine scaffold and fluorine substitution.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by fine chemical suppliers for the custom manufacturing of specialized compounds for client R&D projects.
• Academic Research: Used in university and institutional laboratories for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	1-(4-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid Hydrochloride
CAS No.	732256-85-8
Molecular Formula	C15H17F3NO2 • HCl
Molecular Weight	339.76 g/mol (Free base: 303.30 g/mol)
Synonyms	1-[(4-Trifluoromethyl)benzyl]piperidine-4-carboxylic acid hydrochloride; 4-Piperidinecarboxylic acid, 1-[(4-(trifluoromethyl)phenyl)methyl]-, hydrochloride (1:1); 1-(4-(Trifluoromethyl)benzyl)piperidine-4-carboxylic acid HCl; 1-(4-Trifluoromethylbenzyl)piperidine-4-carboxylic acid hydrochloride; 732256-85-8; 1-(4-Trifluoromethyl-benzyl)-piperidine-4-carboxylic acid hydrochloride salt
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethyl-Benzyl)-Piperidine-4-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and ISO-aligned processes ensures a reliable supply of this high-value intermediate for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.