Description

2-Ethoxy-5-[(4-Methyl-Piperazine-1-Carbonyl)-Amino]-Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive sulfonyl chloride group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), where it serves as a key building block for introducing specific sulfonamide functionalities. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Sulfonamide Derivative Synthesis: Used to introduce the sulfonamide moiety into complex organic molecules during medicinal chemistry research and process development.
• Protease Inhibitor Research: Serves as a precursor in the development of protease inhibitor candidates for various disease targets.
• Kinase Inhibitor Development: Employed in the construction of kinase inhibitor scaffolds, a major class in oncology drug discovery.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.
• Bioconjugation Chemistry: Potential use in creating linker molecules for antibody-drug conjugates (ADCs) or other bioconjugates due to its reactive handle.

Basic Information

Product Name	2-Ethoxy-5-[(4-Methyl-Piperazine-1-Carbonyl)-Amino]-Benzenesulfonyl Chloride
CAS No.	725234-38-8
Molecular Formula	C15H22ClN3O4S
Molecular Weight	375.87 g/mol
Synonyms	5-[(4-Methylpiperazine-1-carbonyl)amino]-2-ethoxybenzenesulfonyl chloride; 2-Ethoxy-5-[(4-methyl-1-piperazinyl)carbonyl]aminobenzenesulfonyl chloride; N-[2-Ethoxy-5-(chlorosulfonyl)phenyl]-4-methylpiperazine-1-carboxamide; CAS 725234-38-8; Sulfonyl chloride intermediate 725234-38-8; 4-Methylpiperazine-1-carboxylic acid [2-ethoxy-5-(chlorosulfonyl)phenyl]amide
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-5-[(4-Methyl-Piperazine-1-Carbonyl)-Amino]-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.