Description

5-Methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine is a specialized heterocyclic compound featuring a fused triazolopyrazine core substituted with methyl and trifluoromethyl groups. This structure is of significant interest for its potential as a key synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the triazolopyrazine scaffold.
• Material Science: Investigated as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trials.

Basic Information

Product Name	5-Methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
CAS No.	723286-86-0
Molecular Formula	C7H5F3N4
Molecular Weight	202.14 g/mol
Synonyms	5-Methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine; 5-Methyl-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; 3-(Trifluoromethyl)-5-methyl-[1,2,4]triazolo[4,3-a]pyrazine; 723286-86-0; 5-Methyl-3-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyrazine
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine adheres to stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, residual solvents, and other critical parameters. Our quality system supports development from research quantities to commercial scale under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.