Description

tert-Butyl 3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients. Its unique fused triazolopyrazine structure, featuring both a reactive bromine substituent and a Boc-protected amine, makes it a critical intermediate for targeted library synthesis and lead optimization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) around the triazolopyrazine core.
• Agrochemical Development: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Peptidomimetic Synthesis: The Boc-protected amine and heterocyclic structure make it suitable for designing and synthesizing peptidomimetics.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	tert-Butyl 3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
CAS No.	723286-80-4
Molecular Formula	C₁₀H₁₅BrN₄O₂
Molecular Weight	303.16 g/mol
Synonyms	7-Boc-3-bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; tert-Butyl 3-bromo-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(6H)-carboxylate; 3-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; BOC-3-Bromo-THP; 723286-80-4; 3-Bromo-7-Boc-5,6,7,8-tetrahydrotriazolopyrazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.