Description

5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a fused triazolopyrazine heterocyclic core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors targeting central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the development of novel drug candidates, particularly those targeting kinase inhibition or GPCR modulation.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Used in route scouting and scale-up synthesis for the manufacturing of complex bioactive molecules.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development of pharmaceutical compounds.
• Academic Research: Employed in university and institutional labs for the study of heterocyclic chemistry and the synthesis of biologically active compounds.

Basic Information

Product Name	5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	723286-79-1
Molecular Formula	C11H16N4O2
Molecular Weight	236.27 g/mol
Synonyms	tert-Butyl 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate; 8H-[1,2,4]Triazolo[4,3-a]pyrazine-7-carboxylic acid, 5,6-dihydro-, 1,1-dimethylethyl ester; 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid 1,1-dimethylethyl ester; 5,6-Dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester; BOC-protected triazolopyrazine; Triazolopyrazine tert-butyl ester
EINECS	Contact for details

Quality Control

Our 5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.