Description

4-Methylpiperazine-2-Carboxylic Acid is a high-purity, functionalized piperazine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a structurally defined scaffold with both a carboxylic acid and a tertiary amine, enabling diverse chemical modifications for creating complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, including protease inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of advanced herbicides, fungicides, and insecticides with specific chiral activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal complex formation.
• Peptidomimetics & Bioactive Compounds: Incorporated into the backbone of peptide analogs to enhance stability, bioavailability, and target specificity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high-purity, specialized heterocyclic acids.

Basic Information

Product Name	4-Methylpiperazine-2-Carboxylic Acid
CAS No.	721876-16-0
Molecular Formula	C6H12N2O2
Molecular Weight	144.17 g/mol
Synonyms	2-Carboxy-4-methylpiperazine; (2S)-4-Methylpiperazine-2-carboxylic acid (for enantiopure forms); 4-Methyl-2-piperazinecarboxylic acid; 4-Methylpiperazine-2-carboxylic acid hydrochloride (salt forms); 2-Piperazinecarboxylic acid, 4-methyl-; L-4-Methylpiperazine-2-carboxylic acid; 4-Methyl-1,4-diazinane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-Methylpiperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.