Description

1,1,1-Trifluoro-4-(4-Methylpiperazin-1-Yl)But-3-En-2-One is a high-value, fluorinated organic building block featuring a reactive enone moiety linked to a methylpiperazine group. This compound matters for its unique structural properties, enabling its use as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to incorporate trifluoromethyl and piperazine motifs into novel active compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Serves as a key synthon in developing novel herbicides, fungicides, and insecticides that benefit from the enhanced bioavailability and metabolic stability imparted by the trifluoromethyl group.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes and activity-based protein profiling (ABPP) agents to study enzyme function and drug-target interactions.
• Material Science Precursor: Employed in the development of advanced organic materials, including liquid crystals and organic semiconductors, where its specific electronic properties are advantageous.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized fluorinated intermediates.

Basic Information

Product Name	1,1,1-Trifluoro-4-(4-Methylpiperazin-1-Yl)But-3-En-2-One
CAS No.	716363-06-3
Molecular Formula	C9H13F3N2O
Molecular Weight	222.21 g/mol
Synonyms	4-(4-Methyl-1-piperazinyl)-1,1,1-trifluoro-2-buten-1-one; 1,1,1-Trifluoro-4-(4-methyl-1-piperazinyl)-2-buten-1-one; 4-(4-Methylpiperazin-1-yl)-1,1,1-trifluorobut-3-en-2-one; 1,1,1-Trifluoro-4-(4-methylpiperazino)-3-buten-2-one; TFMPB; (E)-1,1,1-Trifluoro-4-(4-methylpiperazin-1-yl)but-3-en-2-one (if applicable)
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-(4-Methylpiperazin-1-Yl)But-3-En-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.