Description

3-[4-(2-Chloro-Acetyl)-Piperazin-1-Yl]-Propionitrile is a high-purity, versatile chemical intermediate featuring a reactive chloroacetyl group and a piperazine ring. This compound matters for its critical role as a key building block in the synthesis of complex pharmaceutical molecules, particularly in the development of kinase inhibitors and other biologically active compounds. Pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical synthesis specialists need this intermediate to enable efficient and scalable routes to target molecules, ensuring process reliability and product quality.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents and herbicides.
• Chemical Research & Development: Serves as a versatile building block for constructing complex heterocyclic compounds in academic and industrial research settings.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for producing high-value specialty chemicals.
• Bioconjugation & Probe Development: The reactive chloroacetyl group can be utilized for labeling and modifying biomolecules in biochemical research.

Basic Information

Product Name	3-[4-(2-Chloro-Acetyl)-Piperazin-1-Yl]-Propionitrile
CAS No.	713522-46-4
Molecular Formula	C9H14ClN3O
Molecular Weight	215.68 g/mol
Synonyms	1-(2-Chloroacetyl)-4-(2-cyanoethyl)piperazine; 2-Chloro-1-[4-(2-cyanoethyl)piperazin-1-yl]ethanone; 3-[4-(2-Chloroacetyl)piperazin-1-yl]propanenitrile; 1-(2-Chloroacetyl)-4-(2-cyanoethyl)piperazine; 4-(2-Cyanoethyl)-1-(2-chloroacetyl)piperazine; 2-Chloro-1-(4-(2-cyanoethyl)piperazin-1-yl)ethanone
EINECS	Contact for details

Quality Control

Our 3-[4-(2-Chloro-Acetyl)-Piperazin-1-Yl]-Propionitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical R&D and fine chemical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed to exclude moisture and light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.