Description

4-[4-(2-Fluoro-Benzyl)-Piperazin-1-Yl]-Phenylamine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine-phenylamine core structure with a fluorinated benzyl substituent. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of central nervous system (CNS) and oncology drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking reliable, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly for receptor-targeted therapies.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.
• Biochemical Research: Investigated for its interaction with various biological targets, including GPCRs and kinases.
• Custom Synthesis: A starting material for the custom synthesis of more complex, proprietary molecules for clinical trials.

Basic Information

Product Name	4-[4-(2-Fluoro-Benzyl)-Piperazin-1-Yl]-Phenylamine
CAS No.	709001-17-2
Molecular Formula	C17H20FN3
Molecular Weight	285.36 g/mol
Synonyms	4-[4-(2-Fluorobenzyl)piperazin-1-yl]aniline; 1-(4-Aminophenyl)-4-(2-fluorobenzyl)piperazine; 4-(4-(2-Fluorobenzyl)piperazin-1-yl)benzenamine; 709001-17-2; 4-(4-(2-Fluoro-benzyl)-piperazin-1-yl)-phenylamine; N-(4-Aminophenyl)-N'-(2-fluorobenzyl)piperazine; 2-Fluoro-α-[4-(4-aminophenyl)-1-piperazinyl]methyl]benzene
EINECS	Contact for details

Quality Control

Our production of 4-[4-(2-Fluoro-Benzyl)-Piperazin-1-Yl]-Phenylamine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.