Description

tert-Butyl 4-Tetrahydro-2H-Pyran-4-Ylpiperazine-1-Carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable piperazine and tetrahydropyran rings.
• Library Synthesis: Employed in parallel and combinatorial chemistry for the rapid generation of diverse compound libraries for high-throughput screening (HTS).
• Agrochemical Research: Serves as an intermediate in the development of new pesticides and herbicides, leveraging its heterocyclic structure.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic compounds on scale.

Basic Information

Product Name	tert-Butyl 4-Tetrahydro-2H-Pyran-4-Ylpiperazine-1-Carboxylate
CAS No.	706759-32-2
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	1-Boc-4-(tetrahydro-2H-pyran-4-yl)piperazine; tert-Butyl 4-(oxan-4-yl)piperazine-1-carboxylate; 4-(1-Boc-piperazin-4-yl)tetrahydropyran; 1-(tert-Butoxycarbonyl)-4-(tetrahydro-2H-pyran-4-yl)piperazine; 706759-32-2; Boc-4-(THP-4-yl)piperazine; Piperazine, 4-(tetrahydro-2H-pyran-4-yl)-, 1-(1,1-dimethylethyl) 1-carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Tetrahydro-2H-Pyran-4-Ylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.