Description

1-[4-(4-Amino-2-Chloro-Phenyl)-Piperazin-1-Yl]-2-Methyl-Propan-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperazine-based molecular architecture. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), where precise chemical structure is paramount for biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and receptor-targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological pathways.
• Research & Development (R&D): Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Active Pharmaceutical Ingredient (API) Synthesis: A key building block in the production of complex APIs that incorporate a piperazine moiety.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-[4-(4-Amino-2-Chloro-Phenyl)-Piperazin-1-Yl]-2-Methyl-Propan-1-One
CAS No.	701220-40-8
Molecular Formula	C14H20ClN3O
Molecular Weight	281.78 g/mol
Synonyms	2-Methyl-1-[4-(4-amino-2-chlorophenyl)-1-piperazinyl]-1-propanone; 1-Propanone, 1-[4-(4-amino-2-chlorophenyl)-1-piperazinyl]-2-methyl-; 4-(4-Amino-2-chlorophenyl)piperazin-1-yl isobutyryl ketone; 701220-40-8; 2-Methyl-1-(4-(4-amino-2-chlorophenyl)piperazin-1-yl)propan-1-one
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed to confirm identity, purity, and impurity profile. We adhere to strict in-house specifications designed to meet the demanding requirements of pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider conditions under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.