Description

5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-2,12-Dimethoxy-7-Methyl- 6-((3-Methylphenyl)Methyl)-, Hydrochloride, (-)- is a high-purity, complex organic salt with a defined stereochemistry, making it a valuable intermediate for advanced chemical synthesis. This compound matters for its role as a critical building block in the research and development of novel pharmaceutical agents and other fine chemicals. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking to create new molecules with specific biological or physical properties.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of potential therapeutic compounds, particularly in central nervous system (CNS) and cardiovascular drug research.
• Organic Synthesis Building Block: Used in complex multi-step organic reactions to construct intricate polycyclic frameworks found in natural products and specialty chemicals.
• Biochemical Research: Employed in academic and industrial research to study structure-activity relationships (SAR) and develop new chemical entities.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant scale, optimizing yield and purity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-2,12-Dimethoxy-7-Methyl- 6-((3-Methylphenyl)Methyl)-, Hydrochloride, (-)-
CAS No.	79989-29-0
Molecular Formula	C26H31NO3 • HCl
Molecular Weight	457.99 g/mol (Free base: 421.53 g/mol)
Synonyms	(-)-6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-[(3-methylphenyl)methyl]-5H-dibenzo[d,f]azonin-1-ol hydrochloride; L-689,660 hydrochloride; (1S)-6,7,8,9-Tetrahydro-2,12-dimethoxy-7-methyl-6-[(3-methylphenyl)methyl]-5H-dibenzo[d,f]azonin-1-ol hydrochloride; 5H-Dibenzo[d,f]azonin-1-ol, 6,7,8,9-tetrahydro-2,12-dimethoxy-7-methyl-6-[(3-methylphenyl)methyl]-, hydrochloride, (1S)-; L689660 hydrochloride; A selective sigma ligand precursor.
EINECS	Contact for details

Quality Control

Our 5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-2,12-Dimethoxy-7-Methyl- 6-((3-Methylphenyl)Methyl)-, Hydrochloride, (-)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomeric excess)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.