Description

5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-6-((2,6-Dichlorophenyl)M Ethyl)-2,12-Dimethoxy-7-Methyl-, Hydrochloride, (-)- is a high-purity, complex organic compound belonging to the dibenzazonine class, serving as a critical advanced pharmaceutical intermediate. Its value lies in its specific stereochemistry and functional groups, which are essential for constructing active pharmaceutical ingredients (APIs) with targeted biological activity. This product is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and specialized receptor-targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of proprietary drug candidates and active pharmaceutical ingredients (APIs).
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Preclinical Development: Serves as a critical material for producing batches of compounds required for pharmacological and toxicological testing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-6-((2,6-Dichlorophenyl)M Ethyl)-2,12-Dimethoxy-7-Methyl-, Hydrochloride, (-)-
CAS No.	79989-28-9
Molecular Formula	C27H27Cl2NO3 • HCl
Molecular Weight	516.88 g/mol (for free base: 480.42 g/mol)
Synonyms	(-)-6-(2,6-Dichlorobenzyl)-2,12-dimethoxy-7-methyl-6,7,8,9-tetrahydro-5H-dibenzo[d,f]azonin-1-ol hydrochloride; Levocabastine Impurity; Cabastine Related Compound; Dibenzazonine Derivative; 5H-Dibenzo[d,f]azonin-1-ol, 6,7,8,9-tetrahydro-6-[(2,6-dichlorophenyl)methyl]-2,12-dimethoxy-7-methyl-, hydrochloride, (6S)-; (6S)-6-[(2,6-Dichlorophenyl)methyl]-2,12-dimethoxy-7-methyl-6,7,8,9-tetrahydro-5H-dibenzo[d,f]azonin-1-ol hydrochloride
EINECS	Contact for details

Quality Control

Our 5H-Dibenz(D,F)Azonin-1-Ol, 6,7,8,9-Tetrahydro-6-((2,6-Dichlorophenyl)M Ethyl)-2,12-Dimethoxy-7-Methyl-, Hydrochloride, (-)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (enantiomeric excess)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.