Description

1,2:5,6-Di-o-Isopropylidene-α-L-Glucofuranose is a key chiral building block and protected sugar derivative widely used in organic synthesis. Its primary value lies in its ability to serve as a versatile intermediate for the production of complex pharmaceuticals, nucleosides, and fine chemicals, offering a rigid, protected scaffold for stereoselective reactions. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and biotechnology industries who require high-purity, enantiomerically pure starting materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of antiviral drugs, nucleoside analogs, and other active pharmaceutical ingredients (APIs).
• Chiral Building Block: Utilized in asymmetric synthesis to construct complex molecules with defined stereochemistry for drug discovery and development.
• Carbohydrate Chemistry Research: Serves as a protected form of L-glucose for studying glycosylation reactions and synthesizing complex oligosaccharides.
• Fine Chemical Synthesis: Used in the production of specialty chemicals, flavors, and fragrances that require specific sugar-based architectures.
• Agrochemical Development: Acts as an intermediate in creating novel, biologically active compounds for crop protection.
• Diagnostic Reagent Preparation: Employed in the manufacture of labeled compounds and reagents used in biochemical assays and diagnostics.

Basic Information

Product Name	1,2:5,6-Di-o-Isopropylidene-α-L-Glucofuranose
CAS No.	79943-22-9
Molecular Formula	C₁₂H₂₀O₆
Molecular Weight	260.28 g/mol
Synonyms	1,2:5,6-Di-O-isopropylidene-α-L-glucofuranose; Diacetone-L-glucose; 1,2:5,6-Di-O-(1-methylethylidene)-α-L-glucofuranose; L-(-)-Diacetone glucose; α-L-1,2:5,6-Diisopropylideneglucofuranose; (3aR,5R,6S,6aR)-5-[(R)-1,2-Dihydroxyethyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol
EINECS	Contact for details

Quality Control

Our 1,2:5,6-Di-o-Isopropylidene-α-L-Glucofuranose is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-18.0° to -22.0° (c=1 in H₂O)
Melting Point	158°C - 162°C
Loss on Drying	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.