Description

Ald-Peg1-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a terminal aldehyde group and a protected t-butyl ester. This compound is engineered to serve as a versatile linker and building block in advanced organic synthesis and bioconjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel drug delivery systems, prodrugs, and modified biomolecules. The product offers a reliable solution for introducing functional handles with orthogonal reactivity into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of antibody-drug conjugates (ADCs), peptide therapeutics, and targeted prodrugs.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, and oligonucleotides via the reactive aldehyde group for labeling, cross-linking, or immobilization.
• Polymer Chemistry: Serves as a functional initiator or monomer in the synthesis of tailored, biodegradable PEG-based polymers and hydrogels.
• Material Science: Employed in the surface modification of nanoparticles and other materials to introduce stealth properties (PEGylation) and specific reactive sites.
• Diagnostic Reagent Development: Facilitates the creation of diagnostic assays and imaging probes by linking targeting moieties to reporter molecules.
• Chemical Biology Tool: Enables site-specific modification of biomolecules in research applications for studying structure-function relationships.

Basic Information

Product Name	Ald-Peg1-T-Butyl Ester
CAS No.	2100306-48-5
Molecular Formula	C11H20O5
Molecular Weight	232.27 g/mol
Synonyms	1-Aldehyde-2-(t-butoxycarbonyl)ethoxy Ethane; 3-(2-(2-Formyl-ethoxy)ethoxy)propanoic acid tert-butyl ester; Aldehyde-PEG1-t-butyl ester; t-Butyl 3-(2-(2-formyl-ethoxy)ethoxy)propanoate; 2-[2-(2-Oxoethoxy)ethoxy]acetic Acid 1,1-Dimethylethyl Ester; Boc-PEG1-Aldehyde; tert-Butyl-PEG1-CHO
EINECS	Contact for details

Quality Control

Our Ald-Peg1-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters. We support cGMP manufacturing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as indicated on the label. The product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.