Description

Cyclohexanone Trimethylene Acetal is a versatile cyclic acetal compound, also known as 1,4-Dioxaspiro[4.5]decane. This chemical serves as a crucial protecting group precursor and synthetic intermediate in advanced organic synthesis, valued for its ability to mask ketone functionalities under a wide range of reaction conditions. It is primarily utilized by pharmaceutical, agrochemical, and fine chemical research and development teams for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators.
• Fine Chemical Manufacturing: Serves as a precursor for fragrances, flavors, and specialty performance chemicals.
• Academic & Industrial Research: Employed in methodological development and as a model substrate in organic chemistry research.
• Polymer Chemistry: Can be utilized as a monomer or modifying agent for specialty polymers with tailored properties.
• Ketone Protection Strategy: Acts as a robust protecting group for cyclohexanone derivatives in multi-step synthetic sequences.

Basic Information

Product Name	Cyclohexanone Trimethylene Acetal
CAS No.	180-93-8
Molecular Formula	C9H16O2
Molecular Weight	156.22 g/mol
Synonyms	1,4-Dioxaspiro[4.5]decane; Cyclohexanone, cyclic trimethylene acetal; Cyclohexanone ethylene ketal; 2,6,7-Trioxaspiro[3.5]nonane (incorrect but sometimes listed); Spiro[1,3-dioxolane-2,1'-cyclohexane]; Cyclohexylidene-1,3-dioxolane; NSC 66411
EINECS	205-891-7

Quality Control

Our Cyclohexanone Trimethylene Acetal is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency suitable for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.455 - 1.465
Density (20°C)	1.02 - 1.06 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.