Description

cis-(1S,4S)-n-Methyl-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine Mandelate is a high-purity chiral amine salt, specifically the mandelic acid salt of a tetrahydro-naphthalenamine derivative. This compound is a critical pharmaceutical intermediate, valued for its defined stereochemistry and high chemical purity, which are essential for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular research.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the final or penultimate steps of API manufacturing where high stereochemical purity is mandated.
• Preclinical & Clinical Research: Serves as a standard or starting material in medicinal chemistry for developing new chemical entities (NCEs).
• Asymmetric Synthesis: Employed in chiral pool synthesis and catalysis studies due to its well-defined (1S,4S) configuration.
• Process Chemistry & Scale-Up: Used for process optimization and kilogram-scale production under current Good Manufacturing Practice (cGMP) guidelines.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	cis-(1S,4S)-n-Methyl-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine Mandelate
CAS No.	79617-97-3
Molecular Formula	C26H25Cl2NO3
Molecular Weight	470.39 g/mol
Synonyms	(1S,4S)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (R)-mandelate; (1S,4S)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine mandelate; cis-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (S)-mandelate; Sertraline Intermediate Mandelate Salt; CP-51974-1; Zoloft Intermediate Salt; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (2R)-2-hydroxy-2-phenylacetate
EINECS	Contact for details

Quality Control

Our cis-(1S,4S)-n-Methyl-4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Naphthalenamine Mandelate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identification and assay. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.