Description

(5E,8E,14E)-11,12-Dihydroxyicosa-5,8,14-Trienoic Acid is a specialized dihydroxy fatty acid derivative, specifically a metabolite of arachidonic acid. This compound matters as a key biochemical intermediate in the study of lipoxygenase and cytochrome P450 pathways, offering significant value for research into inflammatory mediators and eicosanoid signaling. It is primarily needed by pharmaceutical R&D laboratories, biochemical researchers, and manufacturers of high-purity reference standards for analytical and diagnostic applications.

Application

• Biochemical Research: Used as a reference standard and intermediate in the study of eicosanoid biosynthesis, particularly pathways involving lipoxygenases.
• Pharmaceutical Development: Serves as a critical metabolite for investigating drug mechanisms related to inflammation and cardiovascular diseases.
• Analytical Standard: Employed as a high-purity calibrant in LC-MS, HPLC, and GC-MS methods for quantifying related eicosanoids in biological samples.
• Cell Signaling Studies: Applied in vitro to elucidate the role of specific hydroxy fatty acids in cellular communication and immune response.
• Enzymology: Used as a substrate to study the activity and inhibition of enzymes like cytochrome P450 epoxygenases.

Basic Information

Product Name	(5E,8E,14E)-11,12-Dihydroxyicosa-5,8,14-Trienoic Acid
CAS No.	79551-82-9
Molecular Formula	C₂₀H₃₄O₄
Molecular Weight	338.48 g/mol
Synonyms	11,12-DiHETE; 11,12-Dihydroxy-5,8,14-eicosatrienoic acid; 11,12-DHET; (5Z,8Z,14Z)-11,12-Dihydroxyicosa-5,8,14-trienoic acid; 11,12-Dihydroxyeicosatrienoic acid; Arachidonic acid 11,12-diol; Epoxy fatty acid diol metabolite
EINECS	Contact for details

Quality Control

Our (5E,8E,14E)-11,12-Dihydroxyicosa-5,8,14-Trienoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in ethanol, DMSO, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.