Description

(5E,8E,11E)-14,15-Dihydroxyicosa-5,8,11-Trienoic Acid is a high-purity, synthetic eicosanoid derivative, specifically a dihydroxy fatty acid. This compound is a critical intermediate and reference standard in biochemical and pharmacological research, particularly for studying lipoxygenase and cytochrome P450 metabolic pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors who require precise, well-characterized bioactive lipids for drug discovery and metabolic studies.

Application

• Biochemical Research: Used as a reference standard and substrate in enzymatic studies, particularly for investigating the 12/15-lipoxygenase and cytochrome P450 epoxygenase pathways.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of more complex eicosanoids and pro-resolving lipid mediators for potential therapeutic applications.
• Cell Signaling Studies: Employed in vitro and ex vivo to study the role of specific hydroxyeicosatrienoic acids (HETEs) and their dihydroxy metabolites in inflammation, angiogenesis, and cellular regulation.
• Analytical Standard: Essential for the calibration of analytical equipment (HPLC, LC-MS) to quantify related metabolites in biological samples for diagnostic and research purposes.
• Metabolomics: A vital component in lipidomics panels for profiling oxylipins and understanding their role in disease states and physiological processes.

Basic Information

Product Name	(5E,8E,11E)-14,15-Dihydroxyicosa-5,8,11-Trienoic Acid
CAS No.	79551-81-8
Molecular Formula	C₂₀H₃₄O₄
Molecular Weight	338.48 g/mol
Synonyms	14,15-DiHETE; 14,15-Dihydroxy-5,8,11-eicosatrienoic acid; 14,15-Dihydroxy-5Z,8Z,11Z-eicosatrienoic acid (stereoisomer); 14,15-DHETE; (5Z,8Z,11Z)-14,15-Dihydroxyicosa-5,8,11-trienoic acid; 14,15-Dihydroxyeicosatrienoic Acid; Arachidonic acid metabolite 14,15-DiHETE
EINECS	Contact for details

Quality Control

Our (5E,8E,11E)-14,15-Dihydroxyicosa-5,8,11-Trienoic Acid is produced under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stability. Certificates of Analysis (COA) detailing results from NMR, HPLC, and MS are provided, confirming compliance with research-grade specifications. We support cGMP standards for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.