Description

1-Piperazinecarboxamide, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-n-(2 -Methylphenyl)-, Hydrochloride is a high-purity, complex heterocyclic compound primarily used as a critical pharmaceutical intermediate. This compound matters because it serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs), where consistent quality and reliable supply are paramount. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the manufacture of advanced active pharmaceutical ingredients (APIs), particularly in oncology and other therapeutic areas.
• Research & Development: Used in medicinal chemistry for the design, synthesis, and screening of new chemical entities with potential biological activity.
• Process Chemistry: Employed in route scouting, optimization, and scale-up studies for efficient and cost-effective API production.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Potential use as a tool compound for studying specific biochemical pathways and target interactions in vitro.

Basic Information

Item	Details
Product Name	1-Piperazinecarboxamide, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-n-(2 -Methylphenyl)-, Hydrochloride
CAS No.	79221-28-6
Molecular Formula	C22H27N7O3 · HCl
Molecular Weight	473.96 g/mol (Free base: 437.50 g/mol)
Synonyms	4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-(2-methylphenyl)piperazine-1-carboxamide hydrochloride; N-(2-Methylphenyl)-4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinecarboxamide hydrochloride; TAK-285 Intermediate; (2-Methylphenyl)[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]methanone hydrochloride; 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-N-(o-tolyl)piperazine-1-carboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Piperazinecarboxamide, 4-(4-Amino-6,7-Dimethoxy-2-Quinazolinyl)-n-(2 -Methylphenyl)-, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.