Description

Insulin, Nle(A2)- CAS NO 78921-99-0 is a synthetic insulin analog where the alanine at position A2 is replaced by norleucine, a modification used in biochemical and pharmaceutical research. This engineered peptide is critical for studying insulin's structure-activity relationships, receptor binding mechanisms, and metabolic pathways. It serves as a valuable tool for researchers and developers in the fields of diabetes research, peptide chemistry, and biopharmaceutical development, enabling the creation of novel therapeutic analogs and diagnostic assays.

Application

• Biochemical Research: A key reference standard for investigating insulin's molecular structure, folding, and stability.
• Drug Discovery: Used as a precursor or model compound in the development of novel insulin analogs with modified pharmacokinetic profiles.
• Receptor Binding Studies: Essential for in vitro assays to study insulin interaction with the insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF-1R).
• Metabolic Pathway Analysis: Employed in cell-based and animal studies to dissect specific signaling pathways related to glucose uptake and metabolism.
• Quality Control & Analytical Standards: Serves as a high-purity standard for calibrating analytical instruments like HPLC and mass spectrometry in pharmaceutical QC labs.
• Academic & Institutional Research: Used in university and research institute laboratories for fundamental studies in endocrinology and peptide science.

Basic Information

Item	Detail
Product Name	Insulin, Nle(A2)-
CAS No.	78921-99-0
Molecular Formula	C257H383N65O77S6
Molecular Weight	5807.9 g/mol
Synonyms	Nle(A2)-Insulin; Norleucine(A2)-Insulin; Insulin (human) [Nle-A2]; A2-Norleucine Insulin; Insulin analog [Nle-A2]; [Nle-A2]-Human Insulin; Insulin, human, 2-L-norleucine-
EINECS	Contact for details

Quality Control

Our Insulin, Nle(A2)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and peptide content analysis. We provide full traceability and Certificates of Analysis (COA) detailing all test results to ensure the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Assessed by receptor binding assay
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in dilute acetic acid or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.