Description

1α,25,26-Trihydroxyvitamin D3 is a biologically active metabolite of vitamin D, representing a high-purity reference standard and key intermediate in pharmaceutical research. This compound is critical for studying calcium and phosphate metabolism, cell differentiation, and immune system modulation. It is primarily utilized by research institutions and pharmaceutical companies developing novel therapeutics for metabolic bone disorders, certain cancers, and autoimmune diseases.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control of vitamin D analogs and related drug substances.
• Biochemical Research: Serves as a critical tool for investigating the non-genomic and genomic signaling pathways of the vitamin D endocrine system.
• Drug Discovery & Development: Acts as a key intermediate or lead compound in the synthesis of novel vitamin D receptor (VDR) agonists and antagonists for therapeutic applications.
• Cell Culture Studies: Employed in *in vitro* studies to examine its effects on cell proliferation, differentiation, and apoptosis in various cell lines.
• Metabolic Studies: Used in research focused on understanding the regulation of calcium homeostasis and bone mineralization.

Basic Information

Product Name	1α,25,26-Trihydroxyvitamin D3
CAS No.	78780-98-0
Molecular Formula	C₂₇H₄₄O₄
Molecular Weight	432.64 g/mol
Synonyms	1α,25,26-Trihydroxycholecalciferol; 1α,25,26-Trihydroxyvitamin D₃; (1S,3R,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25,26-tetrol; 25,26-Dihydroxycalcitriol; 1α,25,26-Trihydroxy-9,10-secocholesta-5,7,10(19)-triene-3β-ol; Vitamin D3 metabolite
EINECS	Contact for details

Quality Control

Our 1α,25,26-Trihydroxyvitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.