Description

(R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Monohydrochloride is a high-purity, single-enantiomer organic compound primarily utilized as a critical chiral intermediate or building block in advanced pharmaceutical synthesis. Its value lies in its complex, fused polycyclic structure which serves as a key scaffold for the development of active pharmaceutical ingredients (APIs) targeting the central nervous system. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who require a reliable source of high-quality, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel psychotropic and neuroactive drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold in the research and process development of new therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for central nervous system (CNS) targets.
• Asymmetric Synthesis: Employed as a sophisticated starting material or intermediate in complex, stereoselective synthetic routes.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.
• Contract Manufacturing & Development (CDMO): A critical material for custom synthesis projects and scale-up services for pharmaceutical clients.

Basic Information

Product Name	(R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Monohydrochloride
CAS No.	78684-62-5
Molecular Formula	C19H20N2•HCl
Molecular Weight	312.84 g/mol (free base: 276.38 g/mol)
Synonyms	(R)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride; (R)-Mirtazapine Impurity; (R)-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride; (R)-Org 3770 Related Compound; (R)-6-Azabicyclo[9.4.0]pentadeca-1(15),11,13-trien-7-one, 2-methyl-, hydrochloride, (2R)-; (R)-Mirtazapine Enantiomer Hydrochloride; (2R)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1,2,3,4,10,14B-Hexahydro-2-Methyldibenzo[C,F]Pyrazino[1,2-A]Azepine Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.